Putting thepresent data into a (patho-) physiological context by taking the distribution ofpHe and NHE1 into account, cells at the edge of the tumour tissue(represented by NHE1-overexpressing cells at pHe7.4) exhibit the lowestcell-cell adhesion and likely a high risk for detachment of cells as a startingpoint in the metastatic behaviour. Here, SLC9A1 is linked to neoplasm.