Melanoma cells escape the “control” ofsurrounding keratinocytes among others through (i) down-regulation of E-cadherin whichmediates adhesion to keratinocytes, (ii) up-regulation of MCAM which can underliemelanoma-melanoma and/or melanoma-fibroblast interaction and (iii) loss of basementmembrane anchorage through altered expression of integrins5. This evidence concerns the gene CDH1 and melanoma.