To identify which members of the OASIS family could contribute to ER stress-induced PRNP expression, OASIS, BBF2H7, CREBH, AIbZIP, and LUMAN transcript levels were assessed by RT-PCR in breast carcinoma MCF-7 cells, human primary neurons and astrocytes treated with the ER stressing drugs BFA, Th or TM (Fig. 1a). Here, CREB3 is linked to breast carcinoma.