MAPK8 and Alzheimer disease: Even though it is difficult to correlate EC biochemical/synaptic changes to the hippocampal dependent behavioural (ORT) impairment in 6- month old AD animals, we might speculate that activation of stress signalling pathways in the EC (p38 and JNK) contribute to the exacerbation of EC dysfunction and trans-synaptic progression of neurodegeneration in target area.