No significant differences were found between the groups of 6 month old mice in the total time spent in exploring object and in the locomotor activity; however either mhAPP or mhAPPxDNMSR mice spent a greater amount of time in exploring the periphery of the box during the habituation phase with respect to WT and DNMSR mice (Supplemental Fig. S4), this suggests that deficiency of RAGE ameliorate memory in older mhAPP mice without any effect on their increased anxiety. The gene discussed is AGER; the disease is Anxiety.