Indeed, using STK11 copy number and mRNA expression data in the Cancer Cell Line Encyclopedia to define cell lines with high (STK11 High, 41 cell lines) and low (STK11 Low, 22 cell lines) STK11 expression, we observed significantly greater palbociclib sensitivity (P=0.002, two-sided T-test) for the STK11 Low group (Supplementary Fig. 6, see Discussion). This evidence concerns the gene STK11 and cancer.