MYC and neoplasm: Because BRD4 inhibitors, such as JQ1, have been shown to be active against MYC-driven tumours, the intimate connection of NSD3-s with BRD4 and with MYC supports the hypothesis that NSD3-s may play a critical role in directing MYC-driven oncogenic programmes and may recruit MYC to a chromatin location through NSD3-s recognition of H3K36me3 and its association with acetylated lysine-BRD4, which warrants further investigation (Fig. 4k).