LCN2 and cyst: Compared with Pkd2-KO mice, we observed a 149% increase in median survival, 31.8% improvement in serum creatinine levels, 15.8% reduction in cyst index, reduced Kim1 (down by 37.9%) and Ngal (down by 39.6%) expression, and a 58.9% decrease in the number of proliferating cyst epithelial cells in Pkd2-miR-17∼92KO mice (Fig. 2e–h and Supplementary Fig. 2).