We observed attenuated cyst growth, lower blood urea nitrogen (BUN) levels, downregulation of Kim1 and Ngal expression, reduced renal fibrosis and lower cyst epithelial proliferation in Pkd1RC/RC; Ksp/Cre;miR-17∼92F/F compared with Pkd1RC/RC; Ksp/Cre mice (Fig. 3e–h and Supplementary Fig. 4). This evidence concerns the gene LCN2 and renal fibrosis.