BCL2 and obesity due to melanocortin 4 receptor deficiency: For example, mNT was implicated in diabetes, obesity, and cancer1, 16, 17, and NAF-1 was implicated in BCL-2-Beclin-1-BIK-dependent autophagy and BCL-2-dependent apoptosis, as well as in neurodegenerative diseases, skeletal muscle maintenance, cancer, and aging1, 10, 11, 12, 13, 14, 15, 17, 18, 21, 22, 23.