PRNP and Alzheimer disease: More recently, Reiniger et al. [59] demonstrated that a tiny punctate (also described as rod-, dot-, or stub-shaped), PrP-specific, p-tau immunoreactivity, positively correlating with PrPSc burden in the neocortex, is consistently found in sCJD brains, irrespective of the molecular subtypes and the AD-related associated pathology.