Pursuing the findings of these studies we demonstrated here, for the first time, that in classic CJD the prion-specific secondary tauopathy especially affects the sCJD subtypes linked to the V2 strain (e.g., VV2 and MV2K) and, most significantly, that in such cases the tauopathy is severe enough to determine a significant increase in p-tau levels in the CSF. The gene discussed is MAPT; the disease is Creutzfeldt Jacob disease.