Among them, CSF protein assays for 14‐3-3, t-tau and p-tau (for the calculation of the t-tau/p-tau ratio) have contributed the most promising and significant results regarding sensitivity and specificity in distinguishing CJD from other RPDs, although with a significant heterogeneity both in terms of number of studies and agreement regarding the relative performance of each assay [6, 9, 12, 17, 18, 22, 30, 44, 48, 60, 63, 67, 68, 72, 79]. Here, MAPT is linked to Creutzfeldt Jacob disease.