In the present study, we aimed to investigate the utility of several CSF biomarkers (14-3-3, t-tau, p-tau, Aβ42 and rec-PrP seeded conversion by RT-QuIC) in the differential diagnosis of CJD from other neurological disorders, in a large non-selected clinical population suspected to be affected by a prion disease. Here, MAPT is linked to Creutzfeldt Jacob disease.