Indeed, the fact that both VV2 and MV2K are sCJD types characterised by plaque-like PrP deposits or even PrP-amyloidosis (MV2K) and are associated, on average, with a higher PrPSc burden than those of the MM(V)1 type [49] somehow fits with the data of both Sikorska et al. [66] and Reiniger et al. [59]. The gene discussed is PRNP; the disease is amyloidosis.