To address whether a higher degree of neuronal AD related tau pathology (in comparison to the other subtypes), besides the tiny neuritic tau profiles, could have contributed to the increased of p-tau levels in sCJD VV2 and MV2K, we also compared the relative distribution of Braak stages and of the mean AD-related score among the major disease subtypes. The gene discussed is MAPT; the disease is Alzheimer disease.