TARDBP and Alzheimer disease: The six post-mortem cases showed mixed pathologies, including criteria-defined CTE in four cases, AD and TDP-43 pathologies in six, CAA in five, and hippocampal sclerosis in two, and others had vascular pathology (N = 1), CBD (N = 1), and LBD (N = 1), and all would have contributed synergistically to the clinical manifestations.