IL6 and neoplasm: This inflammatory response may initiate events that result in the activation of HH signaling, which then promotes expansion of progenitor populations, leading to re-epithelialization of the wound.16-18 Similar to our findings in the current study, levels of IL-6 and IL-8 at the injury site are transient and decrease following re-epithelialization.19 These findings suggest that a wound healing reaction occurs as a result of tissue damage following chemotherapy, which may trigger activation of pathways such as HH by the dying tumor cells.