We have previously shown that HH activation is induced after chemotherapy and promotes increases in stem-like populations in breast cancer cell lines.13 Likewise, both IL-6 and IL-8 have been linked to expansion of stem-like populations after chemotherapy treatment.15 Consistent with other studies, we showed an increase of cells expressing the stem-cell marker AL-DH1A3 following docetaxel treatment (Figure 4). This evidence concerns the gene CXCL8 and breast carcinoma.