This is supported by the fact that inhibitors of vascular calcifications such as fetuin-A and uncarboxylated matrix gla protein are decreased in these patients, suggesting the development of calcified mass.5 The common risk factors for atherosclerotic cardiovascular diseases, such as smoking, dyslipidemia, and arterial hypertension, are not sufficient to explain this pathogenesis. The gene discussed is AHSG; the disease is Hypertension.