BCL6 and diffuse large B-cell lymphoma: DLBCL is the most common lymphoma, accounting for 25% of all non-Hodgkin cases.7 In the elderly (75 years or older), rates of DLBCL increase 1.4% per year.10 The molecular pathogenesis of DLBCL is a complex, multistep process that ultimately results in the transformation and expansion of a malignant clone of germinal or post–germinal B cells.7 Several genetic changes involving BCL-6 and p53 tumor suppressor genes have been found in DLBCL.11, -13