PVR and cancer: Unlike cancer cells that havea weakened antiviral response, macrophages and dendritic cells exposed toPVSRIPO are capable of limiting viral replication and can engage T cells (Brown et al., 2014).PVSRIPO has potential to be used as a treatment against a multitude of cancersas many diverse tumor cells exhibit abundant surface expression of CD155 (Brown et al., 2014; Merrill et al., 2004).