SDC1 and Miyoshi myopathy: HH ligand promoted MM-CSCs (CD138− cells) expansion with no effect on differentiation; whereas, HH pathway blockade with cyclopamine inhibited MM-CSCs expansion, diminished the clonal capacity of the MM cell lines NCI-H929 and KMS12, and decreased the CD138− population through the induction of PC differentiation, suggesting that HH signaling plays a key role in the maintenance of MM-CSCs [83].