EZH2 and Miyoshi myopathy: The increased EZH2 expression in MM cell lines may be mediated by interleukin 6 (IL6) in growth factor-dependent cell lines, caused by IL6-dependent c-Myc or Stat3 transcription factor activation controlling EZH2 transcription or via posttranscriptional miR-26a regulation [55, 57, 58].