In MM patients, promoter hypermethylation of certain tumor suppressor genes including p15, p16, VHL, XAF1, IRF8, TP53, CDKN2A, CDKN2B, DAPK, SOCS1, CDH1, PTGS2, CCND2, and DCC was shown [26–33]. This evidence concerns the gene CDKN2A and Miyoshi myopathy.