Gene silencing hypermethylation of multiple Wnt inhibitors (SFRP2, SFRP3, SFRP5, DKK3, APC, and WIF1) and of E-cadherin, an intracellular adhesion molecule responsible for cytoplasmic anchoring of β-catenin, were associated with constitutive activation of Wnt signaling in MM cells (Table 2) [94]. This evidence concerns the gene CDH1 and Miyoshi myopathy.