Five polymorphisms were associated with TB susceptibility: secreted frizzled-related protein (SFRP1) rs4736958, CTNNB1 (catenin-β1), rs9859392, rs987055, and rs3864004 showed decreased TB risk, meanwhile, SFRP1 rs7832767 was associated with increased risk (57, 58). This evidence concerns the gene SFRP1 and tuberculosis.