CD8A and familial cylindromatosis: Our detailed comparative analysis of P. berghei infection, and the corresponding host immune responses in normal and Cyld−/− mice showed that the presence of CYLD impaired parasite control and augmented brain pathology by promoting hemorrhage, neuroinflammation with activation of astrocytes and microglia, increased accumulation of CD8+ T cells, and apoptosis of endothelial cells.