The clinical manifestations of sepsis, such as fever, hyper coagulation and peripheral hypotension, are derived from the liberation of inflammatory mediators and cytokines such as IL-1β, IL-10, transforming growth factor β (TGF-β), tumor necrosis factor α (TNF-α) and macrophage chemotactic protein (MCP-1; Burkovskiy et al., 2013). The gene discussed is TNF; the disease is Sepsis.