Microglia from aged PS1-APP mice have a 2–5 fold decrease in the expression of the Aβ-binding scavenger receptors RAGE, scavenger receptor A and CD36 compared to their littermate controls (Hickman et al., 2008), which indicates microglial dysfunction in AD and supports the idea that microglia senescence contributes to the pathogenesis of AD. Here, APP is linked to Alzheimer disease.