As high PD-L1 expression in tumor tissues is often associated with the presence of infiltrating T cells (TILs) and IFN-g signature genes, it has been suggested that IFN-g produced by TILs is responsible for the induction of PD-L1 expression in the tumor microenvironment, which might be a mechanism of adaptive resistance exploited by tumor cells. The gene discussed is CD274; the disease is neoplasm.