LRRK2 and Parkinson disease: PD genome-wide association studies (PD-GWAS) suggested different candidate genes as risk factors for sporadic PD [17] among which RAB7L1 and cyclin-G-associated kinase (GAK) were further proposed to interact with LRRK2 forming a complex to promote clearance of Golgi-derived vesicles through macroautophagy [18,19].