Finally, OCR measurements in LICs sorted from those recipients of Fh1fl/fl;FHCyt;Vav-iCre cells that succumbed to AML revealed that Fh1fl/fl;FHCyt;Vav-iCre LICs had defective maximal mitochondrial respiration compared with control and control;FHCyt LICs (not depicted). The gene discussed is VAV1; the disease is acute myeloid leukemia.