FH and acute myeloid leukemia: Given that human acute myeloid leukemia (AML) cells express high levels of FH protein (López-Pedrera et al., 2006; Elo et al., 2014) and enzymatic activity of FH is increased in AML samples compared with cells from normal controls (Tanaka and Valentine, 1961), we next investigated the role for Fh1 in leukemic transformation.