Meis1 and Hoxa9 are frequently overexpressed in several human AML subtypes (Lawrence et al., 1999; Drabkin et al., 2002), and their overexpression in mouse hematopoietic stem and progenitor cells generates self-renewing LICs (Kroon et al., 1998). The gene discussed is HOXA9; the disease is acute myeloid leukemia.