While mutations in human CRB1 are associated with early-onset retinitis pigmentosa (RP12) and Leber congenital amaurosis (LCA) (den Hollander et al., 2001, 1999), it seems to be Crb2 in the mouse that has taken on this function (Alves et al., 2014). Here, CRB2 is linked to Leber congenital amaurosis.