Interestingly, mutations in human CRB1 result in RP12-asssociated blindness (den Hollander et al., 1999), despite the fact that CRB2 and CRB3 are also expressed in the retina (Lemmers et al., 2004; van den Hurk et al., 2005). The gene discussed is CRB1; the disease is blindness (disorder).