We found that the CD169+ Mφ density could act as an independent prognostic factor for OS in both HCC (HR 0.436, 95% CI 0.270–0.703, P = 0.001) and GC (HR 0.587, 95% CI 0.354–0.974, P = 0.039) patients. The gene discussed is SIGLEC1; the disease is hepatocellular carcinoma.