For the rhesus macaque monkey polyomavirus SV40, infection of permissive CV1 or BSC40 monkey cells causes activation of ATM signaling [54, 55], H2AX phosphorylation and Mre11-Rad50-Nbs1 assembly with T-antigen together with other DDR-signaling proteins in viral replication foci. The gene discussed is RAD50; the disease is infection.