In summary, we firstly reported miR-146a was downregulated was in DDP-resistant human NSCLC cells (A549/DDP and SPC-A1/DDP) compared with the sensitive parental cell line A549 and SPC-A1, and further demonstrated that miR-146a might act as a chemosensitivity restorer to DDP in human NSCLC cells by targeting CCNJ and downregulating P-gp, MRP1 and LRP. Here, ABCC1 is linked to non-small cell lung carcinoma.