Abnormal expression of homeobox genes leading to loss of differentiation is observed in breast cancer where expression of Hoxb6, Hoxb7, Hoxc6, Hoxc8, Hoxd4, Hoxd8, Hoxd9, Hoxd10, Hoxa5 is lost in mouse mammary tumours and Hoxa1, Hoxd3, Hoxd12, Msx1, Six1 and Oct3 are instead expressed in cancer, but absent or lowly expressed in the normal differentiated gland [8]. Here, SIX1 is linked to breast cancer.