Of the genes that were altered in all cancer subtypes, the expression of five matched all datasets (HOXC8, HOXC11, HOXD8, PROX1, SIX2), although the overlap was found when considering the expression in the majority of the subtypes as HOXC11 and PROX1 were downregulated in TN CSC. The gene discussed is HOXD8; the disease is cancer.