Regulation of HOXC8 via miRNA 196 has been reported in breast cancer whereby the ration of miR196 and HOXC8 correlates with cell migration and metastasis [36] and methylation of the HOXC8 promoter can induce gene silencing by inducing polymerase II stalling during transcription [50]. Here, HOXC8 is linked to breast carcinoma.