Regarding to neutrophils, Battaglia [100] highlighted that these cells are crucial in the initiation and perpetuation of T1DM, during acute and chronic inflammation, by two proposed mechanisms: (1) one is due the production of pro-inflammatory cytokines, as IL-17, which promote granulopoiesis and consequent neutrophil proliferation and accumulation, leading to prejudice pancreatic cells; and (2) another involves the unintended entrance of bacteria on pancreas that release toxins, leading to the production of IL-6 and IL-8 that attract neutrophils. The gene discussed is IL6; the disease is type 1 diabetes mellitus.