PRTN3 and rheumatoid arthritis: Moreover, Wright et al. [156] summarized the relevant role of certain neutrophil granule enzymes found in high concentrations in RA synovial fluid, such as contributes to the destruction of the articular cartilage and tissue (e.g., elastase, gelatinase and collagenase), promotes inflammation and activate cytokines/receptors (e.g., elastase, cathepsin G, proteinase 3 and lactoferrin), as well as inhibits resolution of chronic inflammation and cartilage repair (e.g., myeloperoxidase and gelatinase-associated lipocalin).