Other functions also were reported, as synovial fluid neutrophils of patients with exacerbation of RA strongly express receptor activator of nuclear factor kappa-B ligand (RANKL) that activate the osteoclastogenesis [166, 194], while peripheral blood neutrophils from both RA patients express B lymphocyte stimulator (BLyS or BAFF), which is implicated in regulation of B cell-dependent autoimmunity [195]. This evidence concerns the gene TNFSF13B and rheumatoid arthritis.