In addition, hyperglycaemia may be a trigger to inflammatory response in T1DM, because it may increase the levels of circulating C-reactive protein (CRP), free fatty acids, CXCL-8, and pro-inflammatory cytokines, such as IL-6, IL-1β and TNF-α [109–111]. This evidence concerns the gene CXCL8 and type 1 diabetes mellitus.