ITGAM and systemic lupus erythematosus: In this regard, Orme and Moah [6] reported important alterations of these cells during the establishment of SLE such as: (1) enhanced apoptosis; (2) enhanced chemotaxis due the overexpression of MCP-1, MIP-1α, CCL5, CXCR4, CXCL12; (3) impaired phagocytosis related to high levels of the complement receptor CR3 (CD11b/ITGAM) and of FCγR1; (4) impaired immune—complex clearance; (5) and impaired superoxide production.