TNF and rheumatoid arthritis: CFA induced RA model on rat is a chronic inflammation including multiple systemic change with synovial hyperplasia resulting from a great proliferative cellular infiltrate of leukocytes and an abnormal increase in levels of many cytokines (particularly IL-1β and TNF-α), significant release of ROS and consequent cartilage and bone destruction with swelling, deformation and loss of function of joint.