In cellular models of diabetes, metformin’s pro-angiogenic endothelial properties were found to be related to (i) AMPK/eNOS activity [35], (ii) a decrease in miR-34a levels and an increase in sirtuin1 expression [37], and (iii) secretion of vascular endothelial growth factor A together with a reduction in mRNA levels of angiogenetic inhibitors [38]. This evidence concerns the gene PRKAA1 and diabetes mellitus.