The top ten pathways of the 27 enriched pathways in upregulated DEGs were ribosome, osteoclast differentiation, lysosome, NF-kappa B signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Chagas disease (American trypanosomiasis), pertussis and salmonella infection. The gene discussed is TNF; the disease is pertussis.