Interestingly, authors also demonstrated that the negative modulation of Cerebron, Ikaros (IKZF1), Aiolos (IKZF3) and Interferon-Regulatory Factor (IRF)-4 induced by Lenalidomide was critical to promote the NKG2D ligands expression on MM cells (Figure 2). Here, IKZF1 is linked to Miyoshi myopathy.