Another major mechanism used by MM cells to escape to NK cell-mediated attack is the modulation of the expression of NKG2D [MHC class I related chain A/B (MICA/B), UL16-binding proteins (ULBPs)] and DNAM-1 (PVR and Nectin-2) ligands on their surface [3, 18, 75]. The gene discussed is CD226; the disease is Miyoshi myopathy.