In the OS-RC-2-BM5 xenograft mouse model, reduced trabeculae and thin bone cortex that are mostly accompanied with osteolytic destruction were commonly observed in long bones [12], and TRAP staining-positive osteoclasts were obviously more examined surrounding the tumor lesions than the non-tumor areas (Supplementary Figure 2), indicating a osteoclast resorption activity. The gene discussed is ACP5; the disease is neoplasm.