However, the resistant cell lines RKO and SW480 both harbored an ATM mutation and no mutations in those genes affected in the responding and intermediate responding CRC cell lines (HNF1A, SMAD4, SMO, ABL, CTNNB1, IDH1, NOTCH1, STK11) (Supplementary Figure 1B). This evidence concerns the gene SMAD4 and colorectal carcinoma.