The known risk of female breast cancer includes BRCA1 or BRCA2 mutation, chest radiation exposure < 30 year, dense breast density, abnormal breast biopsy, family history of ovarian or breast cancer, late parity (age > 30 year) or nulliparity, early menarche (age < 12 year) or late menopause (age > 55 year), hormone-replacement therapy, postmenopausal obesity, white race, alcohol consumption and smoking [4]. The gene discussed is BRCA1; the disease is breast carcinoma.