Here, we report for the first time that several SNPs of the AD-associated genes including CASS4 rs911159, EPHA1 rs10952552, FERMT2 rs4901317, MEF2C rs9293506, PLD3 rs11672825, RIN3 rs1885747, and SLC24A4 rs67063100 may play an important role in the modulation of cognitive aging in old adults in a Taiwanese population. The gene discussed is CASS4; the disease is Alzheimer disease.