Immunohistochemical staining for the endothelial marker endomucin revealed a significant decrease in tumor angiogenesis and vessel count in both the dual LOX/LOXL2 inhibitor treated mice (PXS-S1A) and the LOXL2 specific inhibitor treated mice (PXS-S2B) (Figure 6A and 6B). This evidence concerns the gene EMCN and neoplasm.