Complexes such as Bcl3/NF-kappaB2 complex (governed by BCL3 and NFKB2), vacuolar lumen (governed by CLN5), IPAF inflammasome complex (CASP1, CASP4, NLRC4) help to understand the involvement of inflammation and vascular disorder in AD. The gene discussed is CLN5; the disease is Alzheimer disease.