However, Oral application Lactobacillus rhamnosus GG inhibited allergic sensitization and airway disease in a murine model of asthma by induction of Treg cells, associated with a parallel suppression of the classical Th1-related cytokine (IFN-γ) and Th2-related cytokines (IL-4 and IL-5) [54]. Here, IL4 is linked to hypersensitivity reaction disease.