On the other hand, Herrington et al. [29]–in a study using familiar hypercholesterolemia patients–found that HDL levels to be slightly higher in women carrying PP genotype and Lu et al. [30] found the PP and XX genotype of the PvuII and XbaI polymorphisms were associated with lower serum HDL and ApoA-I levels whereas the XbaI xx genotype was related with lower serum ApoA-II levels. This evidence concerns the gene APOA1 and Hypercholesterolemia.