PHLPP2 and breast cancer: For example, miR-205 suppresses cell migration and invasion via the epithelial-to-mesenchymal transition in human prostate and breast cancer cells [13, 34], In support of its oncogenic function, miR-205 was binds to PETN and PHLPP2 to modulate PI3K/AKT signaling and promote cell proliferation in NSCLC [12].