RUNX2 and osteoporosis: Considering the molecular and immunohistochemical results, the staining observed for RUNX2 showed lightly to moderately expressed pre-osteoblasts at 14 days in the OST group, presenting an increase in transcription factor expression, perhaps in an attempt to recruit a greater number of osteoblasts, offsetting the decrease in osteoblast activity due to the osteoporosis installed on this experimental group.