One focus of these studies was GALT, an important site for early aspects of HIV-1 interaction with the immune system that is home to a large proportion of HIV-1 target cells and is critical for early establishment of HIV-1 infection and pathogenic effects that lead to long-term disease progression (Guy-Grand and Vassalli, 1993; Saksena et al., 2010; Cerf-Bensussan and Guy-Grand, 1991; Belmonte et al., 2007; Mestecky et al., 2009). The gene discussed is GALT; the disease is HIV-1 infection.