Among them, CRABP1, FLNC, IGFBP3, MIR34B, MYOD1, RUNX3, SFRP1 and SFRP2 are found to be co-methylated in the same cluster in both of the TCGA colon adenocarcinoma datasets. The gene discussed is IGFBP3; the disease is colon adenocarcinoma.