In AML, when we compared the published gene list of 45 genes that are aberrantly methylated in all AML subtypes, there is no overlap between those genes and the frequent co-methylation clusters, and only four genes out of 1109 genes were shared between that list and our AML-specific co-methylation clusters (BTBD3, CYP26C1, MCTS1, ZFP161), indicating that most of the AML-linked genes are either not highly variable in their methylation levels or not part of the co-variation network in the TCGA cohort we examined. The gene discussed is BTBD3; the disease is acute myeloid leukemia.