In our study, we found IGF2 and its receptor IGF2BP2/3 in co-methylation clusters from 12 out of 17 datasets (BRCA, LUSC, CESC, STAD, THCA, UCEC, AML, OVCA), and H19 in the co-methylation cluster from STAD and BRCA. Here, IGF2 is linked to acute myeloid leukemia.