EGFR and non-small cell lung carcinoma: BIBW2992 (a newer generation of EGFR inhibitor currently approved for treating NSCLC patients who are refractory to gefitinib and erlotinib), for example, could potentially replace gefitinib, a first-generation EGFR tyrosine kinase inhibitors (TKI) that is increasingly becoming a non-viable solution as cancer cells of NSCLC patients treated with gefitinib inevitably develop resistance and relapse, with 8–10 months of median time to progression [26–28]