We set out to further evaluate the efficacy of bosutinib, which targets Src and Abl, as it is a recently FDA-approved drug for treating BCR-ABL leukemic patients and have no known effects against HNSCC or OSCC, therefore the efficacy of bosutinib is unanticipated when used against OSCC cell lines. This evidence concerns the gene SRC and head and neck squamous cell carcinoma.