SF3B1 and cancer: Since SF3B1 and SF3B3 have been shown to be a core component of the U2 snRNP of the spliceosome and is essential in regulating pre-mRNA splicing in cancer cells4, we hypothesize that the dysregulation of SF3B1 and/or SF3B3 (activation and inhibition) might result in the loss of critical proteins and the expression of variants with aberrant function that influence the survival of cancer cells.