MCL1 and B-cell chronic lymphocytic leukemia: Also, unlike the splicing modulator sudemycin which was recently shown to induce a specific antitumor response in chronic lymphocytic leukemia through alternative splicing of MCL1 to generate its proapoptotic isoform51, no such effect was observed in MCF-7 and MDA-MB-468 treated with JA (Supplementary Fig. S9).