SNRPD1 and breast carcinoma: Similarly, siRNA-mediated depletion of SNRPE or SNRPD1, components of the core spliceosomal heteroheptameric Sm complex, also led to a marked reduction of cell viability in MDA-MB-468 and SKBR3 breast cancer cells, but not in the non-tumoral MCF-10A cells48.