Mutations in SF3B1 have also been reported in myelodysplastic syndromes (MDS) as well as numerous cancers, including acute myeloid leukemia, primary myelofibrosis, chronic myelomonocytic leukemia (CML)12, chronic lymphocytic leukemia (CLL)13, 14, multiple myeloma, uveal melanoma15, 16, 17, 18 and breast cancers19, 20, 21. This evidence concerns the gene SF3B1 and B-cell chronic lymphocytic leukemia.