SF3B3 and cancer: Interestingly, the analysis revealed that 7 targets (SF3B1, SF3B3, SNRPA, SNRPE, SNRPF, HNRNPA3 and EFTUD2) are physically interacting proteins within the spliceosome complex, suggesting that JA might regulate the cancer spliceosome to induce tumor-specific cell death (Fig. 2C).