Vega et al. 21 reported that FMNL3 is a downstream effector of RhoC, a member of the Rho family of small G proteins and a effecter of TGF-β signalling22, which contributes to actin cytoskeleton reassembly and thus plays an important role in tumour cell invasion and metastasis. This evidence concerns the gene TGFB1 and neoplasm.