Considering well differentiated CNE1 cells displayed a low level of FMNL3 expression, we thus forced FMNL3 expression in CNE1 cells, and we observed a typical morphology of EMT in FMNL3-overexpressing cells, this morphological changes were paralleled with associated EMT markers expression (Fig. 3), indicating the sufficiency of FMNL3 in inducing EMT in NPC cells. This evidence concerns the gene FMNL3 and nasopharyngeal carcinoma.