TNF and glioblastoma: As there is an increase in the levels of GrzB, a cytotoxic factor that is partially blocked by XIAP31, 32, 33, and TNF-α, we next assessed whether cocultures of glioblastoma cells with splenocytes from naive mice or mice previously cured of CT-2A intracranial tumours would lead to death of CT-2A cells.