Notably, only ∼50% of profiled cancer cell lines are sensitized to death in combination of SMC and TNF-α or TNF-related apoptosis-inducing ligand (TRAIL); the majority of resistant cell lines are further sensitized to death with the downregulation of the caspase-8 inhibitor, cFLIP (cellular FLICE-like inhibitory protein)22. This evidence concerns the gene CASP8 and cancer.