Analysis of fresh tumour tissue from primary or metastatic sites (Supplementary Table 1) by immunoblotting suggested that Usp9x positivity was more common in metastatic (8/9) than primary tumour (3/9) and correlated with higher Ets-1 (or its isoform) levels in most Usp9x-expressing tumours (Fig. 5k). The gene discussed is ETS1; the disease is neoplasm.