Ets-1 overexpression increased NRAS levels and colony formation (Supplementary Fig. 3a-left and Supplementary Fig. 3b), while Ets-1 KD reduced NRAS levels and blocked long-term survival of tumour cells grown in 3D (Supplementary Fig. 3a, right and Supplementary Fig. 3c). The gene discussed is NRAS; the disease is neoplasm.