Ets-1 overexpression has been documented in many invasive and metastatic cancers, including breast, lung, colon, pancreatic and thyroid cancer25, 29, 30, 31, 32, 33, 34, where Ets-1 drives gene expression associated with cellular differentiation, migration, proliferation, survival and angiogenesis. This evidence concerns the gene ETS1 and metastatic malignant neoplasm.