Moreover, secreted factors (for example, thrombospondin 1 (THBS1) and biglycan (BGN)), and growth factors and cytokines (for example, TGFβ, CXCL12/SDF1, CTGF and FGF2), many of which actively control endothelial and cancer cell behaviour, were differentially regulated between iNFs and iCAFs (Fig. 2g and Supplementary Data 1). Here, FGF2 is linked to cancer.