BGN and cancer: Moreover, secreted factors (for example, thrombospondin 1 (THBS1) and biglycan (BGN)), and growth factors and cytokines (for example, TGFβ, CXCL12/SDF1, CTGF and FGF2), many of which actively control endothelial and cancer cell behaviour, were differentially regulated between iNFs and iCAFs (Fig. 2g and Supplementary Data 1).