INS and obesity due to melanocortin 4 receptor deficiency: • Mice treated with CN extracts showed slower weight gain caused by a high fat, high cholesterol diet• Significantly lower fasting blood glucose in mice treated with CN extracts, with increased insulin sensitivity• Decreased levels of biomarkers of obesity and insulin resistance in mice treated with CN extracts – RBP4, adiponectin, leptin, IL-6 and TNF-α