Sirt1 is upregulated in epilepsy patients (Chen et al., 2013) and after a proepileptic insult in rat models (Chen et al., 2013; Wang et al., 2015; Brennan et al., 2016), yet a role for Sirt1 in seizure protection has also recently been suggested (Wang et al., 2016). The gene discussed is SIRT1; the disease is epilepsy.